Is there a place for corticosteroids or immune modulation in treating Reiter's syndrome and ankylosing spondylitis?

Most patients with Reiter's syndrome (RS) or B27associated conditions respond well to non-steroidal anti-inflammatory agents. Hence there is no need for corticosteroid therapy or immune modulation in mild cases. Aggressive treatment should be considered only if a patient develops severe systemic manifestations such as vasculitis or iridocyclitis or the disease has a prolonged, crippling course that does not respond to conventional therapy.